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Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin

Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological. Binding to heparin increases the stability of FGF1 and is believed to be important in the formation of FGF1·fibroblast growth factor receptor...

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Detalles Bibliográficos
Autores principales:	Zakrzewska, Malgorzata, Wiedlocha, Antoni, Szlachcic, Anna, Krowarsch, Daniel, Otlewski, Jacek, Olsnes, Sjur
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757240/ https://www.ncbi.nlm.nih.gov/pubmed/19574212 http://dx.doi.org/10.1074/jbc.M109.001289

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