Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

BACKGROUND: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix and produce α−smooth muscle actin (α-SMA), type...

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Detalles Bibliográficos
Autores principales: Shi-wen, Xu, Liu, Shangxi, Eastwood, Mark, Sonnylal, Sonali, Denton, Christopher P., Abraham, David J., Leask, Andrew
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757676/
https://www.ncbi.nlm.nih.gov/pubmed/19823586
http://dx.doi.org/10.1371/journal.pone.0007438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757676/
https://www.ncbi.nlm.nih.gov/pubmed/19823586
http://dx.doi.org/10.1371/journal.pone.0007438

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