Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition. In addition, Lcn2 bound to Ent induces release...

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Detalles Bibliográficos
Autores principales: Bachman, Michael A., Miller, Virginia L., Weiser, Jeffrey N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757716/
https://www.ncbi.nlm.nih.gov/pubmed/19834550
http://dx.doi.org/10.1371/journal.ppat.1000622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757716/
https://www.ncbi.nlm.nih.gov/pubmed/19834550
http://dx.doi.org/10.1371/journal.ppat.1000622

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