Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

Polymorphisms in the interleukin-4 receptor α chain (IL-4Rα) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4Rα has been associated with severe asthma, especially i...

Descripción completa

Detalles Bibliográficos
Autores principales: Tachdjian, Raffi, Mathias, Clinton, Al Khatib, Shadi, Bryce, Paul J., Kim, Hong S., Blaeser, Frank, O'Connor, Brian D., Rzymkiewicz, Danuta, Chen, Andrew, Holtzman, Michael J., Hershey, Gurjit K., Garn, Holger, Harb, Hani, Renz, Harald, Oettgen, Hans C., Chatila, Talal A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757875/
https://www.ncbi.nlm.nih.gov/pubmed/19770271
http://dx.doi.org/10.1084/jem.20091480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757875/
https://www.ncbi.nlm.nih.gov/pubmed/19770271
http://dx.doi.org/10.1084/jem.20091480

Ejemplares similares