Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci

The E2A gene products, E12 and E47, are critical regulators of B cell development. However, it remains elusive whether E12 and E47 have overlapping and/or distinct functions during B lymphopoiesis. We have generated mice deficient for either E12 or E47 and examined their roles in B cell maturation....

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Detalles Bibliográficos
Autores principales: Beck, Kristina, Peak, Mandy M., Ota, Takayuki, Nemazee, David, Murre, Cornelis
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757879/
https://www.ncbi.nlm.nih.gov/pubmed/19752184
http://dx.doi.org/10.1084/jem.20090756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757879/
https://www.ncbi.nlm.nih.gov/pubmed/19752184
http://dx.doi.org/10.1084/jem.20090756

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