Nonaminoglycoside compounds induce readthrough of nonsense mutations

Large numbers of genetic disorders are caused by nonsense mutations for which compound-induced readthrough of premature termination codons (PTCs) might be exploited as a potential treatment strategy. We have successfully developed a sensitive and quantitative high-throughput screening (HTS) assay, p...

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Detalles Bibliográficos
Autores principales: Du, Liutao, Damoiseaux, Robert, Nahas, Shareef, Gao, Kun, Hu, Hailiang, Pollard, Julianne M., Goldstine, Jimena, Jung, Michael E., Henning, Susanne M., Bertoni, Carmen, Gatti, Richard A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757881/
https://www.ncbi.nlm.nih.gov/pubmed/19770270
http://dx.doi.org/10.1084/jem.20081940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757881/
https://www.ncbi.nlm.nih.gov/pubmed/19770270
http://dx.doi.org/10.1084/jem.20081940

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