The angiopietin-1–Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice

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The role of the angiopoietin-1 (Ang1)–Tie2 pathway in the pathogenesis of pulmonary arterial hypertension (PAH) is controversial. Although Ang1 is well known to prevent endothelial activation and injury in systemic vascular beds, this pathway has been suggested to mediate pulmonary vascular remodeli...

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Detalles Bibliográficos
Autores principales: Kugathasan, Lakshmi, Ray, Julie Basu, Deng, Yupu, Rezaei, Effat, Dumont, Daniel J., Stewart, Duncan J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757882/
https://www.ncbi.nlm.nih.gov/pubmed/19737862
http://dx.doi.org/10.1084/jem.20090389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757882/
https://www.ncbi.nlm.nih.gov/pubmed/19737862
http://dx.doi.org/10.1084/jem.20090389

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