The cardiac troponin C mutation Leu29Gln found in a patient with hypertrophic cardiomyopathy does not alter contractile parameters in skinned murine myocardium

The present study investigates the effects of the first mutation of troponin C (hcTnC(L29Q)) found in a patient with hypertrophic cardiomyopathy (HCM) on force–pCa relations and the interplay with phosphorylation of sarcomeric PKA substrates. In triton-skinned murine cardiac fibers, the endogenous m...

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Detalles Bibliográficos
Autores principales: Neulen, Axel, Stehle, Robert, Pfitzer, Gabriele
Formato: Texto
Lenguaje:English
Publicado: D. Steinkopff-Verlag 2009
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758205/
https://www.ncbi.nlm.nih.gov/pubmed/19506933
http://dx.doi.org/10.1007/s00395-009-0038-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758205/
https://www.ncbi.nlm.nih.gov/pubmed/19506933
http://dx.doi.org/10.1007/s00395-009-0038-y

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