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The cardiac troponin C mutation Leu29Gln found in a patient with hypertrophic cardiomyopathy does not alter contractile parameters in skinned murine myocardium

The present study investigates the effects of the first mutation of troponin C (hcTnC(L29Q)) found in a patient with hypertrophic cardiomyopathy (HCM) on force–pCa relations and the interplay with phosphorylation of sarcomeric PKA substrates. In triton-skinned murine cardiac fibers, the endogenous m...

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Detalles Bibliográficos
Autores principales:	Neulen, Axel, Stehle, Robert, Pfitzer, Gabriele
Formato:	Texto
Lenguaje:	English
Publicado:	D. Steinkopff-Verlag 2009
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758205/ https://www.ncbi.nlm.nih.gov/pubmed/19506933 http://dx.doi.org/10.1007/s00395-009-0038-y

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