Loss of Yeast Peroxiredoxin Tsa1p Induces Genome Instability through Activation of the DNA Damage Checkpoint and Elevation of dNTP Levels

Peroxiredoxins are a family of antioxidant enzymes critically involved in cellular defense and signaling. Particularly, yeast peroxiredoxin Tsa1p is thought to play a role in the maintenance of genome integrity, but the underlying mechanism is not understood. In this study, we took a genetic approac...

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Detalles Bibliográficos
Autores principales: Tang, Hei-Man Vincent, Siu, Kam-Leung, Wong, Chi-Ming, Jin, Dong-Yan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758587/
https://www.ncbi.nlm.nih.gov/pubmed/19851444
http://dx.doi.org/10.1371/journal.pgen.1000697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758587/
https://www.ncbi.nlm.nih.gov/pubmed/19851444
http://dx.doi.org/10.1371/journal.pgen.1000697

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