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Mechanism of the Efficient Tryptophan Fluorescence Quenching in Human γD-Crystallin Studied by Time-Resolved Fluorescence

[Image: see text] Human γD-crystallin (HγD-Crys) is a two-domain, β-sheet eye lens protein found in the lens nucleus. Its long-term solubility and stability are important to maintain lens transparency throughout life. HγD-Crys has four highly conserved buried tryptophans (Trps), with two in each of...

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Detalles Bibliográficos
Autores principales: Chen, Jiejin, Toptygin, Dmitri, Brand, Ludwig, King, Jonathan
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758765/
https://www.ncbi.nlm.nih.gov/pubmed/18795792
http://dx.doi.org/10.1021/bi800499k