Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity

BACKGROUND: Small molecules that bind reversibly to DNA are among the antitumor drugs currently used in chemotherapy. In the pursuit of a more rational approach to cancer chemotherapy based upon these molecules, it is necessary to exploit the interdependency between DNA-binding affinity, sequence se...

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Detalles Bibliográficos
Autor principal: Portugal, José
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758867/
https://www.ncbi.nlm.nih.gov/pubmed/19758437
http://dx.doi.org/10.1186/1471-2210-9-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758867/
https://www.ncbi.nlm.nih.gov/pubmed/19758437
http://dx.doi.org/10.1186/1471-2210-9-11

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