Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells

Lin28 and Lin28B, two developmentally regulated RNA-binding proteins and proto-oncogenes, selectively inhibit the maturation of let-7 family miRNAs in embryonic stem (ES) cells and certain cancers. Moreover, let-7 precursors (pre-let-7) were previously found to be terminally uridylated in a Lin28-de...

Descripción completa

Detalles Bibliográficos
Autores principales: Hagan, John P., Piskounova, Elena, Gregory, Richard I.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758923/
https://www.ncbi.nlm.nih.gov/pubmed/19713958
http://dx.doi.org/10.1038/nsmb.1676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758923/
https://www.ncbi.nlm.nih.gov/pubmed/19713958
http://dx.doi.org/10.1038/nsmb.1676

Ejemplares similares