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Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells
Lin28 and Lin28B, two developmentally regulated RNA-binding proteins and proto-oncogenes, selectively inhibit the maturation of let-7 family miRNAs in embryonic stem (ES) cells and certain cancers. Moreover, let-7 precursors (pre-let-7) were previously found to be terminally uridylated in a Lin28-de...
Autores principales: | Hagan, John P., Piskounova, Elena, Gregory, Richard I. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758923/ https://www.ncbi.nlm.nih.gov/pubmed/19713958 http://dx.doi.org/10.1038/nsmb.1676 |
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