Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy

A subset of central glutamatergic synapses are coordinatelypruned and matured by unresolved mechanisms during early postnatal life. We report that human epilepsy gene LGI1, mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus. We introduced full-...

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Detalles Bibliográficos
Autores principales: Zhou, Yu-Dong, Lee, Sanghoon, Jin, Zhe, Wright, Moriah, Smith, Stephen E. P., Anderson, Matthew P.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759408/
https://www.ncbi.nlm.nih.gov/pubmed/19701204
http://dx.doi.org/10.1038/nm.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759408/
https://www.ncbi.nlm.nih.gov/pubmed/19701204
http://dx.doi.org/10.1038/nm.2019

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