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Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
A subset of central glutamatergic synapses are coordinatelypruned and matured by unresolved mechanisms during early postnatal life. We report that human epilepsy gene LGI1, mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus. We introduced full-...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759408/ https://www.ncbi.nlm.nih.gov/pubmed/19701204 http://dx.doi.org/10.1038/nm.2019 |