Inhibition of calpain increases LIS1(PAFAH1B1) and partially rescues in vivo phenotypes in a mouse model of lissencephaly

Lissencephaly is a devastating neurological disorder due to defective neuronal migration. LIS1 (or PAFAH1B1) was identified as the gene mutated in lissencephaly patients, and was found to regulate cytoplasmic dynein function and localization. Here, we show that more than half of LIS1 is degraded via...

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Detalles Bibliográficos
Autores principales: Yamada, Masami, Yoshida, Yuko, Mori, Daisuke, Takitoh, Takako, Kengaku, Mineko, Umeshima, Hiroki, Takao, Keizo, Miyakawa, Tsuyoshi, Sato, Makoto, Sorimachi, Hiroyuki, Wynshaw-Boris, Anthony, Hirotsune, Shinji
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759411/
https://www.ncbi.nlm.nih.gov/pubmed/19734909
http://dx.doi.org/10.1038/nm.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759411/
https://www.ncbi.nlm.nih.gov/pubmed/19734909
http://dx.doi.org/10.1038/nm.2023

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