Tumor Suppressor Function of Syk in Human MCF10A In Vitro and Normal Mouse Mammary Epithelium In Vivo

The normal function of Syk in epithelium of the developing or adult breast is not known, however, Syk suppresses tumor growth, invasion, and metastasis in breast cancer cells. Here, we demonstrate that in the mouse mammary gland, loss of one Syk allele profoundly increases proliferation and ductal b...

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Detalles Bibliográficos
Autores principales: Sung, You Me, Xu, Xuehua, Sun, Junfeng, Mueller, Duane, Sentissi, Kinza, Johnson, Peter, Urbach, Elana, Seillier-Moiseiwitsch, Françoise, Johnson, Michael D., Mueller, Susette C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759536/
https://www.ncbi.nlm.nih.gov/pubmed/19829710
http://dx.doi.org/10.1371/journal.pone.0007445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759536/
https://www.ncbi.nlm.nih.gov/pubmed/19829710
http://dx.doi.org/10.1371/journal.pone.0007445

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