An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX Gene

Biosynthesis of the DNA base thymine depends on activity of the enzyme thymidylate synthase (TS) to catalyze the methylation of the uracil moiety of 2’-deoxyuridine-5’-monophosphate (dUMP). All known thymidylate synthases (TSs) rely on an active site residue of the enzyme to activate dUMP1, 2. This...

Descripción completa

Detalles Bibliográficos
Autores principales: Koehn, Eric M., Fleischmann, Todd, Conrad, John A., Palfey, Bruce A., Lesley, Scott A., Mathews, Irimpan I., Kohen, Amnon
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759699/
https://www.ncbi.nlm.nih.gov/pubmed/19370033
http://dx.doi.org/10.1038/nature07973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759699/
https://www.ncbi.nlm.nih.gov/pubmed/19370033
http://dx.doi.org/10.1038/nature07973

Ejemplares similares