Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

BACKGROUND: Cysteine cathepsins are known to primarily cleave their substrates at reducing and acidic conditions within endo-lysosomes. Nevertheless, they have also been linked to extracellular proteolysis, that is, in oxidizing and neutral environments. Although the impact of reducing or oxidizing...

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Detalles Bibliográficos
Autores principales: Jordans, Silvia, Jenko-Kokalj, Saša, Kühl, Nicole M, Tedelind, Sofia, Sendt, Wolfgang, Brömme, Dieter, Turk, Dušan, Brix, Klaudia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759951/
https://www.ncbi.nlm.nih.gov/pubmed/19772638
http://dx.doi.org/10.1186/1471-2091-10-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759951/
https://www.ncbi.nlm.nih.gov/pubmed/19772638
http://dx.doi.org/10.1186/1471-2091-10-23

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