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The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons f...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759982/ https://www.ncbi.nlm.nih.gov/pubmed/19489744 http://dx.doi.org/10.1111/j.1474-9726.2009.00492.x |