Multiple roles for Mre11 at uncapped telomeres

Progressive telomere attrition or uncapping of the shelterin complex elicits a DNA damage response (DDR) as a result of a cell’s inability to distinguish dysfunctional telomeric ends from DNA double-strand breaks (DSBs)1. Telomere deprotection activates both ataxia telangiectasia mutated (ATM) and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Yibin, Guo, Xiaolan, Ferguson, David O., Chang, Sandy
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760383/
https://www.ncbi.nlm.nih.gov/pubmed/19633651
http://dx.doi.org/10.1038/nature08196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760383/
https://www.ncbi.nlm.nih.gov/pubmed/19633651
http://dx.doi.org/10.1038/nature08196

Ejemplares similares