Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death

The phosphatidylinositol-3-kinase-like kinase ATM (Ataxia – telangiectasia mutated) plays a central role in coordinating the DNA damage responses including cell cycle checkpoint control, DNA repair, and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer...

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Detalles Bibliográficos
Autores principales: Tian, Bo, Yang, Qian, Mao, Zixu
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760486/
https://www.ncbi.nlm.nih.gov/pubmed/19151707
http://dx.doi.org/10.1038/ncb1829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760486/
https://www.ncbi.nlm.nih.gov/pubmed/19151707
http://dx.doi.org/10.1038/ncb1829

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