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Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death
The phosphatidylinositol-3-kinase-like kinase ATM (Ataxia – telangiectasia mutated) plays a central role in coordinating the DNA damage responses including cell cycle checkpoint control, DNA repair, and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760486/ https://www.ncbi.nlm.nih.gov/pubmed/19151707 http://dx.doi.org/10.1038/ncb1829 |