Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by the A5 tract is observed, as expected, while the ATATA sequenc...

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Detalles Bibliográficos
Autores principales: Tevis, Denise S., Kumar, Arvind, Stephens, Chad E., Boykin, David W., Wilson, W. David
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760788/
https://www.ncbi.nlm.nih.gov/pubmed/19578063
http://dx.doi.org/10.1093/nar/gkp558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760788/
https://www.ncbi.nlm.nih.gov/pubmed/19578063
http://dx.doi.org/10.1093/nar/gkp558

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