Cargando…

Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by the A5 tract is observed, as expected, while the ATATA sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tevis, Denise S., Kumar, Arvind, Stephens, Chad E., Boykin, David W., Wilson, W. David
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760788/ https://www.ncbi.nlm.nih.gov/pubmed/19578063 http://dx.doi.org/10.1093/nar/gkp558

Ejemplares similares

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
por: Barceló, Francisca, et al.
Publicado: (2007)

Specific minor groove solvation is a crucial determinant of DNA binding site recognition
por: Harris, Lydia-Ann, et al.
Publicado: (2014)

Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes
por: Hall, James P., et al.
Publicado: (2016)

Control of DNA minor groove width and Fis protein binding by the purine 2-amino group
por: Hancock, Stephen P., et al.
Publicado: (2013)

Genome-wide prediction of minor-groove electrostatic potential enables biophysical modeling of protein–DNA binding
por: Chiu, Tsu-Pei, et al.
Publicado: (2017)

A minimal i-motif stabilized by minor groove G:T:G:T tetrads
por: Escaja, Núria, et al.
Publicado: (2012)

Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity
por: Farahat, Abdelbasset A., et al.
Publicado: (2023)

The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding
por: Le, Tung B. K., et al.
Publicado: (2011)

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context
por: Rodríguez, Fabián A., et al.
Publicado: (2007)

A DNA minor groove electronegative potential genome map based on photo-chemical probing
por: Lindemose, Søren, et al.
Publicado: (2011)

Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents
por: Paul, Ananya, et al.
Publicado: (2022)

Self-association of short DNA loops through minor groove C:G:G:C tetrads
por: Viladoms, Júlia, et al.
Publicado: (2009)

The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin
por: Tian, Wei, et al.
Publicado: (2019)

Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif
por: Ghosh, Supratim, et al.
Publicado: (2011)

A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context
por: Paul, Ananya, et al.
Publicado: (2019)

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition
por: Harika, Narinder K., et al.
Publicado: (2016)

Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR
por: Zouhir, Samira, et al.
Publicado: (2013)

Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site
por: Lewis, Edwin A., et al.
Publicado: (2011)

Structures of an all-α protein running along the DNA major groove
por: Yu, Li-Yan, et al.
Publicado: (2016)

Conformation-dependent restraints for polynucleotides: the sugar moiety
por: Kowiel, Marcin, et al.
Publicado: (2020)

Theoretical study of large conformational transitions in DNA: the B↔A conformational change in water and ethanol/water
por: Noy, Agnes, et al.
Publicado: (2007)

Conformational transitions in human translin enable nucleic acid binding
por: Pérez-Cano, Laura, et al.
Publicado: (2013)

Comparing binding site information to binding affinity reveals that Crp/DNA complexes have several distinct binding conformers
por: Holmquist, Peter C., et al.
Publicado: (2011)

What drives the binding of minor groove-directed ligands to DNA hairpins?
por: Lah, Jurij, et al.
Publicado: (2008)

Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove
por: Guo, Pu, et al.
Publicado: (2021)

Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1–RuvBL2 complex
por: López-Perrote, Andrés, et al.
Publicado: (2012)

Conformation-dependent restraints for polynucleotides: I. Clustering of the geometry of the phosphodiester group
por: Kowiel, Marcin, et al.
Publicado: (2016)

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection
por: Buscaglia, Robert, et al.
Publicado: (2013)

Alternative conformation induced by substrate binding for Arabidopsis thalianaN(6)-methyl-AMP deaminase
por: Jia, Qian, et al.
Publicado: (2019)

Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation
por: Kisiala, Marlena, et al.
Publicado: (2020)

Dual conformational recognition by Z-DNA binding protein is important for the B–Z transition process
por: Park, Chaehee, et al.
Publicado: (2020)

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level
por: Pan, Hai, et al.
Publicado: (2017)

The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion
por: Tanzawa, Takehito, et al.
Publicado: (2018)

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines
por: Munde, Manoj, et al.
Publicado: (2014)

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction
por: Jhan, Cyong-Ru, et al.
Publicado: (2021)

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site
por: Chu, Chia-Chieh, et al.
Publicado: (2019)

Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis
por: Smestad, John, et al.
Publicado: (2013)

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
por: Garabedian, Alyssa, et al.
Publicado: (2022)

DNA conformations and their sequence preferences
por: Svozil, Daniel, et al.
Publicado: (2008)

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide
por: Mizuta, R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q5cqde1f38rcjq1fumjklsponb