Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt(II) complexes

Using electrophoresis and replication mapping, we show that the presence of DNA adducts of bifunctional antitumor cisplatin or monodentate [PtCl(dien)]Cl (dien = diethylenetriamine) in the substrate DNA inhibits eukaryotic topoisomerase 1 (top1) action, the adducts of cisplatin being more effective....

Descripción completa

Detalles Bibliográficos
Autores principales: Malina, Jaroslav, Vrana, Oldrich, Brabec, Viktor
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760795/
https://www.ncbi.nlm.nih.gov/pubmed/19589806
http://dx.doi.org/10.1093/nar/gkp580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760795/
https://www.ncbi.nlm.nih.gov/pubmed/19589806
http://dx.doi.org/10.1093/nar/gkp580

Ejemplares similares