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The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts
Specific guanine-rich sequence motifs in the human genome have considerable potential to form four-stranded structures known as G-quadruplexes or G4 DNA. The enrichment of these motifs in key chromosomal regions has suggested a functional role for the G-quadruplex structure in genomic regulation. In...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761265/ https://www.ncbi.nlm.nih.gov/pubmed/19617376 http://dx.doi.org/10.1093/nar/gkp590 |