Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside–RNA hairpin loop interactions

Herein, we report the identification of RNA hairpin loops that bind derivatives of kanamycin A, tobramycin, neamine, and neomycin B via two-dimensional combinatorial screening, a method that screens chemical and RNA spaces simultaneously. An arrayed aminoglycoside library was probed for binding to a...

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Detalles Bibliográficos
Autores principales: Paul, Dustin J., Seedhouse, Steven J., Disney, Matthew D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761267/
https://www.ncbi.nlm.nih.gov/pubmed/19726586
http://dx.doi.org/10.1093/nar/gkp594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761267/
https://www.ncbi.nlm.nih.gov/pubmed/19726586
http://dx.doi.org/10.1093/nar/gkp594

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