Cargando…

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

The accessory subunit of mitochondrial DNA polymerase γ, POLGβ, functions as a processivity factor in vitro. Here we show POLGβ has additional roles in mitochondrial DNA metabolism. Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids, which often contain multiple copies of the mit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Re, M., Sembongi, H., He, J., Reyes, A., Yasukawa, T., Martinsson, P., Bailey, L. J., Goffart, S., Boyd-Kirkup, J. D., Wong, T. S., Fersht, A. R., Spelbrink, J. N., Holt, I. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761280/ https://www.ncbi.nlm.nih.gov/pubmed/19625489 http://dx.doi.org/10.1093/nar/gkp614

Ejemplares similares

Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication
por: Rajala, Nina, et al.
Publicado: (2014)

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication
por: Cluett, Tricia J, et al.
Publicado: (2018)

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA
por: Bailey, Laura J., et al.
Publicado: (2009)

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB
por: Plaza-G.A., Ismael, et al.
Publicado: (2023)

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA
por: Rosa, Ilaria Dalla, et al.
Publicado: (2009)

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response
por: Pohjoismäki, Jaakko L. O., et al.
Publicado: (2012)

Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M(1)dG
por: Cline, Susan D., et al.
Publicado: (2010)

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
por: Moss, Chloe F., et al.
Publicado: (2017)

Direct removal of RNA polymerase barriers to replication by accessory replicative helicases
por: Hawkins, Michelle, et al.
Publicado: (2019)

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
por: Hirota, Kouji, et al.
Publicado: (2015)

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein
por: Morin, José A., et al.
Publicado: (2017)

Single-stranded DNA recruitment mechanism in replication origin unwinding by DnaA initiator protein and HU, an evolutionary ubiquitous nucleoid protein
por: Yoshida, Ryusei, et al.
Publicado: (2023)

Oxidative stress induces degradation of mitochondrial DNA
por: Shokolenko, Inna, et al.
Publicado: (2009)

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells
por: Bailey, Laura J, et al.
Publicado: (2019)

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function
por: Szczesny, Bartosz, et al.
Publicado: (2014)

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
por: Sen, Doyel, et al.
Publicado: (2016)

Oxidative stress increases M(1)dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA
por: Wauchope, Orrette R, et al.
Publicado: (2018)

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
por: Doimo, Mara, et al.
Publicado: (2023)

Polymerase manager protein UmuD directly regulates Escherichia coli DNA polymerase III α binding to ssDNA
por: Chaurasiya, Kathy R., et al.
Publicado: (2013)

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein
por: Kaur, Parminder, et al.
Publicado: (2018)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
por: Tahbaz, Nasser, et al.
Publicado: (2012)

DNA polymerase β uses its lyase domain in a processive search for DNA damage
por: Howard, Michael J., et al.
Publicado: (2017)

Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level
por: Lehmann, Diana, et al.
Publicado: (2019)

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
por: Morin, José A., et al.
Publicado: (2015)

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

Site-directed mutagenesis of the χ subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction
por: Naue, Natalie, et al.
Publicado: (2011)

Regulation of nuclear DNA damage response by mitochondrial morphofunctional pathway
por: Oanh, Nguyen Thi Kim, et al.
Publicado: (2022)

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53
por: Wong, Tuck Seng, et al.
Publicado: (2009)

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β
por: Asagoshi, Kenjiro, et al.
Publicado: (2012)

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles
por: Herzog, Mareike, et al.
Publicado: (2021)

Metal-induced DNA translocation leads to DNA polymerase conformational activation
por: Kirby, Thomas W., et al.
Publicado: (2012)

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle
por: Chatre, Laurent, et al.
Publicado: (2013)

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures
por: Northam, Matthew R., et al.
Publicado: (2014)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
por: Jemt, Elisabeth, et al.
Publicado: (2011)

DNA polymerase η contributes to genome-wide lagging strand synthesis
por: Kreisel, Katrin, et al.
Publicado: (2019)

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases δ and η
por: McCulloch, Scott D., et al.
Publicado: (2009)

Membrane association of mitochondrial DNA facilitates base excision repair in mammalian mitochondria
por: Boesch, Pierre, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_nor0vgk2sruq9mgih1ijpah82i