Biochemical and mutagenic analysis of I-CreII reveals distinct but important roles for both the H-N-H and GIY-YIG motifs

Homing endonucleases typically contain one of four conserved catalytic motifs, and other elements that confer tight DNA binding. I-CreII, which catalyzes homing of the Cr.psbA4 intron, is unusual in containing two potential catalytic motifs, H-N-H and GIY-YIG. Previously, we showed that cleavage by...

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Detalles Bibliográficos
Autores principales: Corina, Laura E., Qiu, Weihua, Desai, Ami, Herrin, David L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761285/
https://www.ncbi.nlm.nih.gov/pubmed/19651876
http://dx.doi.org/10.1093/nar/gkp624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761285/
https://www.ncbi.nlm.nih.gov/pubmed/19651876
http://dx.doi.org/10.1093/nar/gkp624

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