Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance

BACKGROUND: Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and is frequently complicated by depression and cognitive impairment. sPD likely has multiple interacting causes that include increased oxidative stress damage to...

Descripción completa

Detalles Bibliográficos
Autores principales: Arthur, Charles R, Morton, Stephanie L, Dunham, Lisa D, Keeney, Paula M, Bennett, James P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761382/
https://www.ncbi.nlm.nih.gov/pubmed/19775436
http://dx.doi.org/10.1186/1750-1326-4-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761382/
https://www.ncbi.nlm.nih.gov/pubmed/19775436
http://dx.doi.org/10.1186/1750-1326-4-37

Ejemplares similares