Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation

BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusua...

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Detalles Bibliográficos
Autores principales: Smith, Terry K., Vasileva, Nadina, Gluenz, Eva, Terry, Stephen, Portman, Neil, Kramer, Susanne, Carrington, Mark, Michaeli, Shulamit, Gull, Keith, Rudenko, Gloria
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762041/
https://www.ncbi.nlm.nih.gov/pubmed/19855834
http://dx.doi.org/10.1371/journal.pone.0007532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762041/
https://www.ncbi.nlm.nih.gov/pubmed/19855834
http://dx.doi.org/10.1371/journal.pone.0007532

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