In silico saturation mutagenesis and docking screening for the analysis of protein-ligand interaction: the Endothelial Protein C Receptor case study

BACKGROUND: The design of mutants in protein functional regions, such as the ligand binding sites, is a powerful approach to recognize the determinants of specific protein activities in cellular pathways. For an exhaustive analysis of selected positions of protein structure large scale mutagenesis t...

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Detalles Bibliográficos
Autores principales: Chiappori, Federica, D'Ursi, Pasqualina, Merelli, Ivan, Milanesi, Luciano, Rovida, Ermanna
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762068/
https://www.ncbi.nlm.nih.gov/pubmed/19828079
http://dx.doi.org/10.1186/1471-2105-10-S12-S3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762068/
https://www.ncbi.nlm.nih.gov/pubmed/19828079
http://dx.doi.org/10.1186/1471-2105-10-S12-S3

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