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Evaluation of genome coverage and fidelity of multiple displacement amplification from single cells by SNP array
The scarce amount of DNA contained in a singe cell is a limiting factor for clinical application of preimplantation genetic diagnosis mainly due to the risk of misdiagnosis caused by allele dropout and the difficulty in obtaining copy number variations in all 23 pairs of chromosomes. Multiple displa...
Autores principales: | Ling, Jiawei, Zhuang, Guanglun, Tazon-Vega, Barbara, Zhang, Chenhui, Cao, Baoqiang, Rosenwaks, Zev, Xu, Kangpu |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762374/ https://www.ncbi.nlm.nih.gov/pubmed/19671595 http://dx.doi.org/10.1093/molehr/gap066 |
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