ErbB2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor

The orphan receptor tyrosine kinase ErbB2 (HER2/Neu) transforms cells when overexpressed1, and is an important therapeutic target in human cancer2,3. Structural studies4,5 have suggested that the oncogenic (and ligand-independent) signalling properties of ErbB2 result from the absence of a key intra...

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Detalles Bibliográficos
Autores principales: Alvarado, Diego, Klein, Daryl E., Lemmon, Mark A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762480/
https://www.ncbi.nlm.nih.gov/pubmed/19718021
http://dx.doi.org/10.1038/nature08297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762480/
https://www.ncbi.nlm.nih.gov/pubmed/19718021
http://dx.doi.org/10.1038/nature08297

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