Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

The HSPs (hereditary spastic paraplegias) are genetic conditions in which there is distal degeneration of the longest axons of the corticospinal tract, resulting in spastic paralysis of the legs. The gene encoding spartin is mutated in Troyer syndrome, an HSP in which paralysis is accompanied by add...

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Detalles Bibliográficos
Autores principales: Edwards, Thomas L., Clowes, Virginia E., Tsang, Hilda T. H., Connell, James W., Sanderson, Christopher M., Luzio, J. Paul, Reid, Evan
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762690/
https://www.ncbi.nlm.nih.gov/pubmed/19580544
http://dx.doi.org/10.1042/BJ20082398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762690/
https://www.ncbi.nlm.nih.gov/pubmed/19580544
http://dx.doi.org/10.1042/BJ20082398

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