The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://www.ncbi.nlm.nih.gov/pubmed/19561607
http://dx.doi.org/10.1038/ng.403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://www.ncbi.nlm.nih.gov/pubmed/19561607
http://dx.doi.org/10.1038/ng.403

Ejemplares similares