The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

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Autores principales: Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://www.ncbi.nlm.nih.gov/pubmed/19561607
http://dx.doi.org/10.1038/ng.403
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author Pomerantz, Mark M.
Ahmadiyeh, Nasim
Jia, Li
Herman, Paula
Verzi, Michael P.
Doddapaneni, Harshavardhan
Beckwith, Christine A.
Chan, Jennifer A.
Hills, Adam
Davis, Matt
Yao, Keluo
Kehoe, Sarah M.
Lenz, Heinz-Josef
Haiman, Christopher A.
Yan, Chunli
Henderson, Brian E.
Frenkel, Baruch
Barretina, Jordi
Bass, Adam
Tabernero, Josep
Baselga, José
Regan, Meredith M.
Manak, J. Robert
Shivdasani, Ramesh
Coetzee, Gerhard A.
Freedman, Matthew L.
author_facet Pomerantz, Mark M.
Ahmadiyeh, Nasim
Jia, Li
Herman, Paula
Verzi, Michael P.
Doddapaneni, Harshavardhan
Beckwith, Christine A.
Chan, Jennifer A.
Hills, Adam
Davis, Matt
Yao, Keluo
Kehoe, Sarah M.
Lenz, Heinz-Josef
Haiman, Christopher A.
Yan, Chunli
Henderson, Brian E.
Frenkel, Baruch
Barretina, Jordi
Bass, Adam
Tabernero, Josep
Baselga, José
Regan, Meredith M.
Manak, J. Robert
Shivdasani, Ramesh
Coetzee, Gerhard A.
Freedman, Matthew L.
author_sort Pomerantz, Mark M.
collection PubMed
description An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2). These data provide strong support for a biological mechanism underlying this non-protein coding risk variant.
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spelling pubmed-27634852010-02-01 The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer Pomerantz, Mark M. Ahmadiyeh, Nasim Jia, Li Herman, Paula Verzi, Michael P. Doddapaneni, Harshavardhan Beckwith, Christine A. Chan, Jennifer A. Hills, Adam Davis, Matt Yao, Keluo Kehoe, Sarah M. Lenz, Heinz-Josef Haiman, Christopher A. Yan, Chunli Henderson, Brian E. Frenkel, Baruch Barretina, Jordi Bass, Adam Tabernero, Josep Baselga, José Regan, Meredith M. Manak, J. Robert Shivdasani, Ramesh Coetzee, Gerhard A. Freedman, Matthew L. Nat Genet Article An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2). These data provide strong support for a biological mechanism underlying this non-protein coding risk variant. 2009-06-28 2009-08 /pmc/articles/PMC2763485/ /pubmed/19561607 http://dx.doi.org/10.1038/ng.403 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pomerantz, Mark M.
Ahmadiyeh, Nasim
Jia, Li
Herman, Paula
Verzi, Michael P.
Doddapaneni, Harshavardhan
Beckwith, Christine A.
Chan, Jennifer A.
Hills, Adam
Davis, Matt
Yao, Keluo
Kehoe, Sarah M.
Lenz, Heinz-Josef
Haiman, Christopher A.
Yan, Chunli
Henderson, Brian E.
Frenkel, Baruch
Barretina, Jordi
Bass, Adam
Tabernero, Josep
Baselga, José
Regan, Meredith M.
Manak, J. Robert
Shivdasani, Ramesh
Coetzee, Gerhard A.
Freedman, Matthew L.
The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title_full The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title_fullStr The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title_full_unstemmed The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title_short The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer
title_sort 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with myc in colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://www.ncbi.nlm.nih.gov/pubmed/19561607
http://dx.doi.org/10.1038/ng.403
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