Cargando…

The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763485/ https://www.ncbi.nlm.nih.gov/pubmed/19561607 http://dx.doi.org/10.1038/ng.403

Ejemplares similares

Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus
por: Jia, Li, et al.
Publicado: (2009)

Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer
por: Yang, Yuan, et al.
Publicado: (2016)

Association of rs6983267 Polymorphism and Thyroid Cancer Susceptibility: A Systematic Review and Meta-Analysis
por: Li, Jingdong, et al.
Publicado: (2016)

The association of CCAT2 rs6983267 SNP with MYC expression and progression of uterine cervical cancer in the Polish population
por: Łaźniak, Sebastian, et al.
Publicado: (2018)

Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population
por: Jabraili, Masoud, et al.
Publicado: (2023)

The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population
por: Wu, Zhiyuan, et al.
Publicado: (2021)

Association of rs6983267 at 8q24, HULC rs7763881 polymorphisms and serum lncRNAs CCAT2 and HULC with colorectal cancer in Egyptian patients
por: Shaker, Olfat G., et al.
Publicado: (2017)

Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects
por: Zhu, Man, et al.
Publicado: (2017)

LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer
por: Yu, Wei-Ling, et al.
Publicado: (2021)

An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice
por: Ting, Man-Chun, et al.
Publicado: (2012)

Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium : Evidence for gene duplications and extensive gene clustering
por: Doddapaneni, Harshavardhan, et al.
Publicado: (2005)

Comprehensive Functional Annotation of Seventy-One Breast Cancer Risk Loci
por: Rhie, Suhn Kyong, et al.
Publicado: (2013)

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations
por: Shah, Maitri Y., et al.
Publicado: (2018)

No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue
por: Prokunina-Olsson, Ludmila, et al.
Publicado: (2009)

Association between 8q24 (rs13281615 and rs6983267) polymorphism and breast cancer susceptibility: a meta-analysis involving 117,355 subjects
por: Zhang, Yafei, et al.
Publicado: (2016)

Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis
por: Thean, Lai Fun, et al.
Publicado: (2021)

Comparative analysis of ESTs involved in grape responses to Xylella fastidiosa infection
por: Lin, Hong, et al.
Publicado: (2007)

PRINCESS: comprehensive detection of haplotype resolved SNVs, SVs, and methylation
por: Mahmoud, Medhat, et al.
Publicado: (2021)

Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion
por: Little, Gillian H., et al.
Publicado: (2012)

VitisExpDB: A database resource for grape functional genomics
por: Doddapaneni, Harshavardhan, et al.
Publicado: (2008)

Analysis of the genome-wide variations among multiple strains of the plant pathogenic bacterium Xylella fastidiosa
por: Doddapaneni, Harshavardhan, et al.
Publicado: (2006)

Impact of COVID-19 Restrictions on Stage of Breast Cancer at Presentation and Time to Treatment at an Urban Safety-Net Hospital
por: Kapp, Kelly A., et al.
Publicado: (2022)

ASO Visual Abstract: Impact of COVID-19 Restrictions on Stage of Breast Cancer at Presentation and Time to Treatment at an Urban Safety-Net Hospital
por: Kapp, Kelly A., et al.
Publicado: (2022)

SOX15 Governs Transcription in Human Stratified Epithelia and a Subset of Esophageal Adenocarcinomas
por: Sulahian, Rita, et al.
Publicado: (2015)

Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity
por: Jia, Li, et al.
Publicado: (2008)

Microarray-Based Capture of Novel Expressed Cell Type–Specific Transfrags (CoNECT) to Annotate Tissue-Specific Transcription in Drosophila melanogaster
por: Hong, X., et al.
Publicado: (2012)

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
por: Baniwal, Sanjeev K, et al.
Publicado: (2010)

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity
por: Kim, Tae-Hee, et al.
Publicado: (2014)

Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
por: MacConaill, Laura E., et al.
Publicado: (2009)

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
por: MacConaill, Laura E., et al.
Publicado: (2010)

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
por: MacConaill, Laura E., et al.
Publicado: (2009)

PrimerSNP: a web tool for whole-genome selection of allele-specific and common primers of phylogenetically-related bacterial genomic sequences
por: Yao, Jiqiang, et al.
Publicado: (2008)

Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients
por: Schumacher, Steven E., et al.
Publicado: (2017)

Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells
por: Rhie, Suhn Kyong, et al.
Publicado: (2014)

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci
por: Hazelett, Dennis J., et al.
Publicado: (2014)

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer
por: Sulahian, Rita, et al.
Publicado: (2013)

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine
por: Jadhav, Unmesh, et al.
Publicado: (2016)

Comparative phylogenomics and multi-gene cluster analyses of the Citrus Huanglongbing (HLB)-associated bacterium Candidatus Liberibacter
por: Doddapaneni, Harshavardhan, et al.
Publicado: (2008)

Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis
por: Pomerantz, Mark M., et al.
Publicado: (2010)

Effects of Environmental Conditions on the Fitness Penalty in Herbicide Resistant Brachypodium hybridum
por: Frenkel, Eyal, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1h5mck2mha0hn0lejpnneff82p