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Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target
Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial. Artemisinins also exhibit selective cytotoxicity against cancer cells in vitro and in vi...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764339/ https://www.ncbi.nlm.nih.gov/pubmed/19862332 http://dx.doi.org/10.1371/journal.pone.0007472 |