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Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties

We report for the first time abnormalities in cardiac ventricular electrophysiology in a genetically modified murine model lacking the Scn3b gene (Scn3b(−/−)). Scn3b(−/−) mice were created by homologous recombination in embryonic stem (ES) cells. RT-PCR analysis confirmed that Scn3b mRNA was express...

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Detalles Bibliográficos
Autores principales:	Hakim, Parvez, Gurung, Iman S., Pedersen, Thomas H., Thresher, Rosemary, Brice, Nicola, Lawrence, Jason, Grace, Andrew A., Huang, Christopher L.-H.
Formato:	Texto
Lenguaje:	English
Publicado:	Pergamon Press 2008
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764399/ https://www.ncbi.nlm.nih.gov/pubmed/19351516 http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.005

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