RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences

Potent antiviral RNAi can be induced by intracellular expression of short hairpin RNAs (shRNAs) and artificial microRNAs (miRNAs). Expression of shRNA and miRNA results in target mRNA degradation (perfect base pairing) or translational repression (partial base pairing). Although efficient inhibition...

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Detalles Bibliográficos
Autores principales: Liu, Ying Poi, Gruber, Jens, Haasnoot, Joost, Konstantinova, Pavlina, Berkhout, Ben
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764431/
https://www.ncbi.nlm.nih.gov/pubmed/19656954
http://dx.doi.org/10.1093/nar/gkp644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764431/
https://www.ncbi.nlm.nih.gov/pubmed/19656954
http://dx.doi.org/10.1093/nar/gkp644

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