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Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four huma...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764449/ https://www.ncbi.nlm.nih.gov/pubmed/19692585 http://dx.doi.org/10.1093/nar/gkp630 |
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| author | Lim, Kah Wai Alberti, Patrizia Guédin, Aurore Lacroix, Laurent Riou, Jean-François Royle, Nicola J. Mergny, Jean-Louis Phan, Anh Tuân |
| author_facet | Lim, Kah Wai Alberti, Patrizia Guédin, Aurore Lacroix, Laurent Riou, Jean-François Royle, Nicola J. Mergny, Jean-Louis Phan, Anh Tuân |
| author_sort | Lim, Kah Wai |
| collection | PubMed |
| description | Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA. |
| format | Text |
| id | pubmed-2764449 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27644492009-10-20 Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad Lim, Kah Wai Alberti, Patrizia Guédin, Aurore Lacroix, Laurent Riou, Jean-François Royle, Nicola J. Mergny, Jean-Louis Phan, Anh Tuân Nucleic Acids Res Structural Biology Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA. Oxford University Press 2009-10 2009-08-19 /pmc/articles/PMC2764449/ /pubmed/19692585 http://dx.doi.org/10.1093/nar/gkp630 Text en © The Author 2009. Published by Oxford University Press. http://creativecommons.org/licenses?by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses?by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Structural Biology Lim, Kah Wai Alberti, Patrizia Guédin, Aurore Lacroix, Laurent Riou, Jean-François Royle, Nicola J. Mergny, Jean-Louis Phan, Anh Tuân Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title | Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title_full | Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title_fullStr | Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title_full_unstemmed | Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title_short | Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad |
| title_sort | sequence variant (ctaggg)(n) in the human telomere favors a g-quadruplex structure containing a g·c·g·c tetrad |
| topic | Structural Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764449/ https://www.ncbi.nlm.nih.gov/pubmed/19692585 http://dx.doi.org/10.1093/nar/gkp630 |
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