Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

RNA aptamers against bovine prion protein (bPrP) were obtained, most of the obtained aptamers being found to contain the r(GGAGGAGGAGGA) (R12) sequence. Then, it was revealed that R12 binds to both bPrP and its β-isoform with high affinity. Here, we present the structure of R12. This is the first re...

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Detalles Bibliográficos
Autores principales: Mashima, Tsukasa, Matsugami, Akimasa, Nishikawa, Fumiko, Nishikawa, Satoshi, Katahira, Masato
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764455/
https://www.ncbi.nlm.nih.gov/pubmed/19666719
http://dx.doi.org/10.1093/nar/gkp647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764455/
https://www.ncbi.nlm.nih.gov/pubmed/19666719
http://dx.doi.org/10.1093/nar/gkp647

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