Cargando…

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

RNA aptamers against bovine prion protein (bPrP) were obtained, most of the obtained aptamers being found to contain the r(GGAGGAGGAGGA) (R12) sequence. Then, it was revealed that R12 binds to both bPrP and its β-isoform with high affinity. Here, we present the structure of R12. This is the first re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mashima, Tsukasa, Matsugami, Akimasa, Nishikawa, Fumiko, Nishikawa, Satoshi, Katahira, Masato
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764455/ https://www.ncbi.nlm.nih.gov/pubmed/19666719 http://dx.doi.org/10.1093/nar/gkp647

Ejemplares similares

Anti-prion activity of an RNA aptamer and its structural basis
por: Mashima, Tsukasa, et al.
Publicado: (2013)

Development and structural determination of an anti-PrP(C) aptamer that blocks pathological conformational conversion of prion protein
por: Mashima, Tsukasa, et al.
Publicado: (2020)

Unexpected A-form formation of 4′-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance
por: Matsugami, Akimasa, et al.
Publicado: (2008)

Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition
por: Hayashi, Tomohiko, et al.
Publicado: (2014)

Elucidation of the mode of interaction in the UP1–telomerase RNA–telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity
por: Nagata, Takashi, et al.
Publicado: (2008)

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
por: Marušič, Maja, et al.
Publicado: (2013)

Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides
por: Kovačič, Matic, et al.
Publicado: (2020)

G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol
por: Tsukakoshi, Kaori, et al.
Publicado: (2021)

Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
por: Shim, Ji Wook, et al.
Publicado: (2009)

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
por: Russo Krauss, Irene, et al.
Publicado: (2016)

Direct experimental evidence for quadruplex–quadruplex interaction within the human ILPR
por: Schonhoft, Joseph D., et al.
Publicado: (2009)

Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter
por: Todd, Alan K., et al.
Publicado: (2007)

Insights into the G-rich VEGF-binding aptamer V7t1: when two G-quadruplexes are better than one!
por: Moccia, Federica, et al.
Publicado: (2019)

Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes
por: Huang, Xiao-Xi, et al.
Publicado: (2014)

KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units
por: Podbevšek, Peter, et al.
Publicado: (2016)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

Guiding the folding of G-quadruplexes through loop residue interactions
por: Jana, Jagannath, et al.
Publicado: (2022)

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation
por: Cian, Anne De, et al.
Publicado: (2007)

Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions
por: Ohyama, Takako, et al.
Publicado: (2012)

Stability and kinetics of G-quadruplex structures
por: Lane, Andrew N., et al.
Publicado: (2008)

Bulges in left-handed G-quadruplexes
por: Das, Poulomi, et al.
Publicado: (2021)

On the interaction of an anticancer trisubstituted naphthalene diimide with G-quadruplexes of different topologies: a structural insight
por: Platella, Chiara, et al.
Publicado: (2020)

Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences
por: Gaynutdinov, Timur I., et al.
Publicado: (2008)

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Folding and misfolding pathways of G-quadruplex DNA
por: Marchand, Adrien, et al.
Publicado: (2016)

Duplex formation in a G-quadruplex bulge
por: Ngoc Nguyen, Thi Quynh, et al.
Publicado: (2020)

Water spines and networks in G-quadruplex structures
por: Li, Kevin, et al.
Publicado: (2020)

Kinetics and mechanism of G-quadruplex formation and conformational switch in a G-quadruplex of PS2.M induced by Pb(2+)
por: Liu, Wei, et al.
Publicado: (2012)

Quadruplexes in ‘Dicty’: crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome
por: Guédin, Aurore, et al.
Publicado: (2018)

Stability of intramolecular quadruplexes: sequence effects in the central loop
por: Guédin, Aurore, et al.
Publicado: (2009)

Guanine base stacking in G-quadruplex nucleic acids
por: Lech, Christopher Jacques, et al.
Publicado: (2013)

G-quadruplex structure of an anti-proliferative DNA sequence
por: Do, Ngoc Quang, et al.
Publicado: (2017)

Structure of two G-quadruplexes in equilibrium in the KRAS promoter
por: Marquevielle, Julien, et al.
Publicado: (2020)

A DNA G-quadruplex/i-motif hybrid
por: Chu, Betty, et al.
Publicado: (2019)

Sugar-modified G-quadruplexes: effects of LNA-, 2′F-RNA– and 2′F-ANA-guanosine chemistries on G-quadruplex structure and stability
por: Li, Zhe, et al.
Publicado: (2014)

Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis
por: Davlieva, Milya, et al.
Publicado: (2014)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine
por: Duchardt-Ferner, Elke, et al.
Publicado: (2020)

A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes
por: Kumar, Niti, et al.
Publicado: (2008)

Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex
por: Gill, Michelle L., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_7u2ppmc94oh68p6pbo5fd9s3br