Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators

BACKGROUND: Intracellular proteases constitute a class of promising drug discovery targets. Methods for high throughput screening against these targets are generally limited to in vitro biochemical assays that can suffer many technical limitations, as well as failing to capture the biological contex...

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Detalles Bibliográficos
Autores principales: Hayashi, Hideki, Cuddy, Michael, Shu, Vincent Chih-Wen, Yip, Kenneth W., Madiraju, Charitha, Diaz, Paul, Matsuyama, Toshifumi, Kaibara, Muneshige, Taniyama, Kohtaro, Vasile, Stefan, Sergienko, Eduard, Reed, John C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764853/
https://www.ncbi.nlm.nih.gov/pubmed/19876397
http://dx.doi.org/10.1371/journal.pone.0007655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764853/
https://www.ncbi.nlm.nih.gov/pubmed/19876397
http://dx.doi.org/10.1371/journal.pone.0007655

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