Cargando…

Arylamine N-Acetyltransferases in Mycobacteria

Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sim, Edith, Sandy, James, Evangelopoulos, Dimitrios, Fullam, Elizabeth, Bhakta, Sanjib, Westwood, Isaac, Krylova, Anna, Lack, Nathan, Noble, Martin
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers Ltd. 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764864/ https://www.ncbi.nlm.nih.gov/pubmed/18680471 http://dx.doi.org/10.2174/138920008784892100

Ejemplares similares

Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa
por: Westwood, Isaac M, et al.
Publicado: (2007)

Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages
por: Abuhammad, Areej, et al.
Publicado: (2012)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
por: Laurieri, Nicola, et al.
Publicado: (2014)

3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria
por: Agre, Neha, et al.
Publicado: (2020)

Arylamine N-Acetyltransferase Is Required for Synthesis of Mycolic Acids and Complex Lipids in Mycobacterium bovis BCG and Represents a Novel Drug Target
por: Bhakta, Sanjib, et al.
Publicado: (2004)

Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
por: Sim, E, et al.
Publicado: (2014)

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis
por: Fayez, Diman, et al.
Publicado: (2018)

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis
por: Barra, Fabio, et al.
Publicado: (2018)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
por: Liu, Xinning, et al.
Publicado: (2021)

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1
por: Kawamura, Akane, et al.
Publicado: (2008)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
por: Mahasneh, Amjad, et al.
Publicado: (2012)

Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase
por: Kleinpenning, Fleur, et al.
Publicado: (2018)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
por: Salazar-González, Raúl A., et al.
Publicado: (2022)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system
por: Wakefield, Larissa, et al.
Publicado: (2008)

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
por: Turiján-Espinoza, Eneida, et al.
Publicado: (2018)

Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
por: Vangenot, Christelle, et al.
Publicado: (2019)

Correction to Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase
por: Kleinpenning, Fleur, et al.
Publicado: (2019)

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2
por: Conway, Louis P., et al.
Publicado: (2020)

N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.
por: Watanabe, M, et al.
Publicado: (1994)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
por: Doll, Mark A., et al.
Publicado: (2017)

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
por: Camporez, João Paulo, et al.
Publicado: (2017)

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis
por: Evangelopoulos, Dimitrios, et al.
Publicado: (2014)

A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1
por: Laurieri, Nicola, et al.
Publicado: (2013)

Polymorphisms in the Human Cytochrome P450 and Arylamine N-Acetyltransferase: Susceptibility to Head and Neck Cancers
por: Khlifi, Rim, et al.
Publicado: (2013)

Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases
por: Stepp, Marcus W., et al.
Publicado: (2015)

Treatment of Rats with Apocynin Has Considerable Inhibitory Effects on Arylamine N-Acetyltransferase Activity in the Liver
por: Francis, Sheena, et al.
Publicado: (2016)

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes
por: Salazar-González, Raúl A., et al.
Publicado: (2020)

Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines
por: Tiang, Jacky M, et al.
Publicado: (2015)

Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66
por: Guo, Shuqi, et al.
Publicado: (2020)

Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
por: Sabbagh, Audrey, et al.
Publicado: (2011)

Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
por: Hou, Zhi-duo, et al.
Publicado: (2014)

Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells
por: Hong, Kyung U., et al.
Publicado: (2022)

From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2
por: Laurieri, Nicola, et al.
Publicado: (2014)

Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens
por: Hein, David W., et al.
Publicado: (2022)

Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens
por: Duval, Romain, et al.
Publicado: (2016)

Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis
por: Hong, Kyung U., et al.
Publicado: (2022)

Arylamines suppress their own activation and that of nitroarenes in V79 Chinese hamster cells by competing for acetyltransferases.
por: Kiefer, F, et al.
Publicado: (1994)

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N-Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies
por: Ragunathan, Nilusha, et al.
Publicado: (2010)

Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance
por: Minchin, Rodney F., et al.
Publicado: (2018)

Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer
por: Endo, Yumi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uhrq5a5b26mdhbuq41a1mh9okt