Genomic Instability and DNA Damage Responses in Progeria Arising from Defective Maturation of Prelamin A

Progeria syndromes have in common a premature aging phenotype and increased genome instability. The susceptibility to DNA damage arises from a compromised repair system, either in the repair proteins themselves or in the DNA damage response pathways. The most severe progerias stem from mutations aff...

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Detalles Bibliográficos
Autores principales: Musich, Phillip R., Zou, Yue
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765059/
https://www.ncbi.nlm.nih.gov/pubmed/19851476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765059/
https://www.ncbi.nlm.nih.gov/pubmed/19851476

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