Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

Recently identified genetic forms of short QT syndrome (SQTS) are associated with an increased risk of arrhythmia and sudden death. The SQT3 variant is associated with an amino-acid substitution (D172N) in the KCNJ2-encoded Kir2.1 K(+) channel. In this study, whole-cell action potential (AP) clamp r...

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Detalles Bibliográficos
Autores principales: El Harchi, Aziza, McPate, Mark J., Zhang, Yi hong, Zhang, Henggui, Hancox, Jules C.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2009
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765655/
https://www.ncbi.nlm.nih.gov/pubmed/19285083
http://dx.doi.org/10.1016/j.yjmcc.2009.02.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765655/
https://www.ncbi.nlm.nih.gov/pubmed/19285083
http://dx.doi.org/10.1016/j.yjmcc.2009.02.027

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